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您好，建议您使用mouse_event或者 Cursor.Position来实现。例如：
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1. 您需要将鼠标移动dx, dy的位置。
Public Sub MouseMoveBy(ByVal dx As Integer, ByVal dy As Integer)
Cursor.Position = New Point(Cursor.Position.X + dx, Cursor.Position.Y + dy)
End Sub
或者
Public Sub MouseMoveBy(ByVal dx As Integer, ByVal dy As Integer)
mouse_event(0, dx, dy, 0, 0)
End Sub
2. 您需要将鼠标移动到x, y的位置
Public Sub MouseMoveTo(ByVal x As Integer, ByVal y As Integer)
Cursor.Position = New Point(x, y)
End Sub
请您试一下。
调用api
在Visual Baisc点虐 中的声明：
Declare Sub mouse_event Lib "user32" (ByVal dwFlags As Long, ByVal dx As Long, ByVal dy As Long, ByVal cButtons As Long, ByVal dwExtraInfo As Long)
Public Const MOUSEEVENTF_LEFTDOWN = H2 '模拟鼠标左键按下
Public Const MOUSEEVENTF_LEFTUP = H4 ’模拟鼠标左键释放
Public Const MOUSEEVENTF_MIDDLEDOWN = H20 '模拟鼠标中间键按下
Public Const MOUSEEVENTF_MIDDLEUP = H40 '模拟鼠标中间键释放
Public Const MOUSEEVENTF_RIGHTDOWN = H8 '模拟鼠标右键按下
Public Const MOUSEEVENTF_RIGHTUP = H10 '模拟鼠标右键释放
Public Const MOUSEEVENTF_MOVE = H1 '模拟鼠标指针移动
例：
mouse_event MOUSEEVENTF_LEFTDOWN,10,10,0,0
'在（10，10）模拟鼠标左键按下
几乎找不到真正VB.NET的api，都是自己将VB的api改成VB.NET的api，我的理解是声明中对应输入是H的地方保留Long，其他的Long改成Integer，既然VB.NET连MSDN都找不到较全的api说明，不保证api的用法在VB.NET其他版本中适用。
给你个好玩的例子，包括鼠标的隐藏（Ctrl_↓）、显示（Ctrl_↑），移动、点击
在Form1上放上2个TextBox，其中TextBox1.Multiline = True，并且面积大些，2个Button，运行后在TextBox1中点击一下会记录位置，移开鼠标，点击移动或点击Button，可模拟在TextBox1中的点击
Public Class Form1
Public My_MousePosition As Point
'模拟鼠标移动、点击
Declare Sub mouse_event Lib "user32" (ByVal dwFlags As Long, ByVal dx As Integer, ByVal dy As Integer, ByVal cButtons As Long, ByVal dwExtraInfo As Long)
'定义光标的位置
Declare Function SetCursorPos Lib "user32" Alias "SetCursorPos" (ByVal x As Integer, ByVal y As Integer) As Integer
'鼠标的隐藏
Declare Function ShowCursor Lib "user32" Alias "ShowCursor" (ByVal bShow As Integer) As Integer
Private Sub Form1_Load(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles MyBase.Load
TextBox1.Multiline = True
Button1.Text = "点击"
Button2.Text = "移动"
Me.KeyPreview = True
End Sub
Private Sub Form1_KeyDown(ByVal sender As Object, ByVal e As System.Windows.Forms.KeyEventArgs) Handles Me.KeyDown
If e.Control And e.KeyCode = Keys.Down Then ShowCursor(0)
If e.Control And e.KeyCode = Keys.Up Then ShowCursor(1)
End Sub
Private Sub Form1_MouseMove(ByVal sender As Object, ByVal e As System.Windows.Forms.MouseEventArgs) Handles Me.MouseMove
TextBox2.Text = MousePosition.X " " MousePosition.Y
End Sub
Private Sub TextBox1_MouseClick(ByVal sender As Object, ByVal e As System.Windows.Forms.MouseEventArgs) Handles TextBox1.MouseClick
My_MousePosition = MousePosition
TextBox1.Text = My_MousePosition.X " " My_MousePosition.Y vbCrLf
End Sub
Private Sub Button1_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button1.Click
SetCursorPos(My_MousePosition.X, My_MousePosition.Y)
mouse_event(H2, 0, 0, 0, 0)
mouse_event(H4, 0, 0, 0, 0)
End Sub
Private Sub Button2_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button2.Click
SetCursorPos(My_MousePosition.X, My_MousePosition.Y)
End Sub
End Class
其中
mouse_event Lib "user32" (ByVal dwFlags As Long
的dwFlags的代码是
Const MOUSEEVENTF_LEFTDOWN = H2
Const MOUSEEVENTF_LEFTUP = H4
Const MOUSEEVENTF_MIDDLEDOWN = H20
Const MOUSEEVENTF_MIDDLEUP = H40
Const MOUSEEVENTF_MOVE = H1
Const MOUSEEVENTF_ABSOLUTE = H8000
Const MOUSEEVENTF_RIGHTDOWN = H8
Const MOUSEEVENTF_RIGHTUP = H10