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最简单的加速运动示例，直接拷贝代码，即可用方向键控制控件移动
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Public Class 最简单的加速运动
Dim 左右, 上下 As Integer
Dim X, Y, VX, VY, VA As Double
Dim WithEvents 时钟 As New Timer
Dim WithEvents 移动控件 As New Label
Private Sub Form1_Load(sender As Object, e As EventArgs) Handles MyBase.Load
Me.KeyPreview = True
VA = 0.5
X = 300.0
Y = 300.0
移动控件.BackColor = Color.MediumPurple
移动控件.Size = New Size(60, 60)
Controls.Add(移动控件)
时钟.Interval = 25
时钟.Enabled = True
End Sub
Private Sub Form1_KeyDown(sender As Object, e As KeyEventArgs) Handles MyBase.KeyDown
If e.KeyCode = Keys.Up Then 上下 = -1
If e.KeyCode = Keys.Down Then 上下 = 1
If e.KeyCode = Keys.Left Then 左右 = -1
If e.KeyCode = Keys.Right Then 左右 = 1
End Sub
Private Sub Form1_KeyUp(sender As Object, e As KeyEventArgs) Handles MyBase.KeyUp
If e.KeyCode = Keys.Up Then 上下 = 0
If e.KeyCode = Keys.Down Then 上下 = 0
If e.KeyCode = Keys.Left Then 左右 = 0
If e.KeyCode = Keys.Right Then 左右 = 0
End Sub
Private Sub 时钟_Tick(sender As Object, e As EventArgs) Handles 时钟.Tick
VX = Math.Min(VX + 左右 * VA, 10)
VY = Math.Min(VY + 上下 * VA, 10)
X += VX
Y += VY
If X 0 Then X = 2 : VX = -VX
If Y 0 Then Y = 2 : VY = -VY
If X Width - 移动控件.Width Then X = Width - 移动控件.Width - 2 : VX = -VX
If Y Height - 移动控件.Height Then Y = Height - 移动控件.Height - 2 : VY = -VY
移动控件.Location = New Point(X, Y)
End Sub
End Class
很简单，你怎么不先问我，还在这提问。用api函数，钩子，设置成全局钩子，然后对钩取来的message消息不做处理，也不返回，这样屏蔽了键盘了。钩子函数api好像是什么hook的那个，还有钩子函数的返回函数，以整个自定义函数的指针作参数
这是不可能完成的任务，.NET平台不存在开发驱动的能力，你要想在驱动层对键盘操作，最好使用C,C++来实现，比较方便。 像现在一些比较出名的网络游戏，都是在驱动层进行保护的。
Public Class Form2
Private Sub Form2_Load(ByVal sender As Object, ByVal e As System.EventArgs) Handles Me.Load
AddHandler Label1.MouseEnter, AddressOf LabelMouseEnter
AddHandler Label2.MouseEnter, AddressOf LabelMouseEnter
AddHandler Label1.MouseLeave, AddressOf LabelMouseLeave
AddHandler Label2.MouseLeave, AddressOf LabelMouseLeave
AddHandler Label1.MouseDown, AddressOf LabelMouseDown
AddHandler Label2.MouseDown, AddressOf LabelMouseDown
End Sub
Private Sub LabelMouseEnter(ByVal sender As Object, ByVal e As System.EventArgs)
Dim c As Label = DirectCast(sender, Label)
c.BackColor = Color.DodgerBlue
End Sub
Private Sub LabelMouseDown(ByVal sender As Object, ByVal e As System.Windows.Forms.MouseEventArgs)
Dim c As Label = DirectCast(sender, Label)
Form1.TextBox1.Text = c.Text
End Sub
Private Sub LabelMouseLeave(ByVal sender As Object, ByVal e As System.EventArgs)
Dim c As Label = DirectCast(sender, Label)
c.BackColor = SystemColors.Control
End Sub
End Class